Preclinical Meaning: Definition, Examples, and Translations
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preclinical
[priหหklษชnษชkษl ]
Definition
medical research
Preclinical refers to the research and experimentation that occurs before clinical trials involve human participants. This stage typically involves laboratory experiments, animal studies, and other forms of scientific testing. It aims to gather initial efficacy and safety data for new drugs or treatments.
Synonyms
developmental, experimental, preliminary.
Examples of usage
- The drug successfully passed the preclinical trials.
- Preclinical studies are essential for drug approval.
- Researchers are conducting preclinical tests on a new therapy.
Translations
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Interesting Facts
Science
- Preclinical research often utilizes animal models to predict how new treatments might work in humans.
- Safety and dosage studies are key components of preclinical testing to ensure new therapies aren't harmful before human trials.
- Innovative technologies, such as computer modeling, are increasingly used in preclinical trials to simulate drug effects.
History
- Modern preclinical testing methods gained prominence in the mid-20th century with the rise of pharmaceutical companies.
- Historically, many medicines were tested directly on humans without preclinical studies, leading to dangerous outcomes.
Regulatory Frameworks
- Before advancing to human trials, studies must meet the regulatory standards set by organizations like the FDA and EMA.
- Preclinical results are documented in detailed reports, which must be submitted for review before any human testing can begin.
Pop Culture
- Films and books often explore the ethical dilemmas of preclinical testing, focusing on the balance between innovation and safety.
- Characters in medical dramas may engage in preclinical research, showcasing the behind-the-scenes challenges of drug development.
Origin of 'preclinical'
Main points about word origin
- The prefix 'pre-' comes from Latin, meaning 'before', indicating a stage that occurs earlier than clinical testing.
- The term 'clinical' comes from Greek 'klinikos', meaning 'bedside', referring to the practice of treating patients.
The term 'preclinical' is derived from the prefix 'pre-' meaning 'before', and 'clinical', which originates from the Greek word 'klinikos', meaning 'pertaining to the bedside'. The term has gained prominence in the fields of medicine and pharmacology as the understanding of drug development processes has evolved. Its use became more widespread in the late 20th century, particularly as the pharmaceutical industry began to prioritize rigorous testing and validation of drugs before they reach human trials. As research methodologies advanced, 'preclinical' came to denote a specific phase in the drug development pipeline, emphasizing the importance of ensuring safety and efficacy before any clinical studies involving humans can commence.